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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HCN1
All Species:
1.82
Human Site:
S695
Identified Species:
5
UniProt:
O60741
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60741
NP_066550.2
890
98796
S695
P
Q
P
S
A
I
L
S
P
C
S
Y
T
T
A
Chimpanzee
Pan troglodytes
XP_526930
460
51719
L275
P
V
Y
T
A
T
S
L
S
H
S
N
L
H
S
Rhesus Macaque
Macaca mulatta
XP_001092625
537
59913
S352
S
Y
T
T
A
V
C
S
P
P
V
Q
S
P
L
Dog
Lupus familis
XP_855255
901
99693
A706
P
P
V
Q
S
P
L
A
A
R
T
F
H
Y
A
Cat
Felis silvestris
Mouse
Mus musculus
O88704
910
102413
L716
A
S
P
T
A
S
Q
L
S
L
M
Q
Q
P
Q
Rat
Rattus norvegicus
Q9JKB0
910
102403
L716
A
S
P
T
A
S
Q
L
S
L
M
Q
Q
P
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_425050
1188
129247
P865
G
Q
F
Q
V
G
S
P
P
A
G
S
G
Q
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_685414
901
101015
G705
Q
M
G
N
P
L
M
G
S
G
S
V
Q
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24278
665
75805
D479
G
K
L
S
V
V
G
D
D
G
I
T
V
L
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
49.8
58.4
94
N.A.
93.1
93.3
N.A.
N.A.
49
N.A.
60.5
N.A.
20.6
N.A.
N.A.
N.A.
Protein Similarity:
100
50.4
59.5
95.2
N.A.
94
94.4
N.A.
N.A.
57.8
N.A.
70.3
N.A.
38.5
N.A.
N.A.
N.A.
P-Site Identity:
100
20
20
20
N.A.
13.3
13.3
N.A.
N.A.
13.3
N.A.
6.6
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
33.3
40
46.6
N.A.
20
20
N.A.
N.A.
13.3
N.A.
33.3
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
23
0
0
0
56
0
0
12
12
12
0
0
0
0
34
% A
% Cys:
0
0
0
0
0
0
12
0
0
12
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
12
12
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
12
0
0
0
0
0
0
0
0
12
0
0
0
% F
% Gly:
23
0
12
0
0
12
12
12
0
23
12
0
12
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
12
0
0
12
12
0
% H
% Ile:
0
0
0
0
0
12
0
0
0
0
12
0
0
0
0
% I
% Lys:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
12
0
0
12
23
34
0
23
0
0
12
12
12
% L
% Met:
0
12
0
0
0
0
12
0
0
0
23
0
0
0
0
% M
% Asn:
0
0
0
12
0
0
0
0
0
0
0
12
0
0
0
% N
% Pro:
34
12
34
0
12
12
0
12
34
12
0
0
0
34
12
% P
% Gln:
12
23
0
23
0
0
23
0
0
0
0
34
34
12
34
% Q
% Arg:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% R
% Ser:
12
23
0
23
12
23
23
23
45
0
34
12
12
12
12
% S
% Thr:
0
0
12
45
0
12
0
0
0
0
12
12
12
12
0
% T
% Val:
0
12
12
0
23
23
0
0
0
0
12
12
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
12
12
0
0
0
0
0
0
0
0
12
0
12
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _